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Laboratory for Intelligent

Global Health & Humanitarian

Response Technologies

Web-based objective and structured assessment of point-of-care lung ultrasound skills in resource-limited settings

Veronique Suttels, Ines Chichignoud, Prudence Ablo Wachinou, Jacques Daniel Du Toit, Pierre-André Mans, Juan Manuel Blanco, Gildas Agodokpessi, Thomas Brahier, Mary-Anne Hartley, Elena Garcia & Noémie Boillat-Blanco

2024

TabSeq: A Framework for Deep Learning on Tabular Data via Sequential Ordering

Al Zadid Sultan Bin Habib, Kesheng Wang, Mary-Anne Hartley, Gianfranco Doretto and Donald A. Adjeroh

2024

MEDITRON: Open Medical Foundation Models Adapted for Clinical Practice

Zeming Chen, Alejandro Hernández Cano, Angelika Romanou, Antoine Bonnet, Kyle Matoba, Francesco Salvi, Matteo Pagliardini, Simin Fan, Andreas Köpf, Amirkeivan Mohtashami, Alexandre Sallinen, Alireza Sakhaeirad, Vinitra Swamy, Igor Krawczuk, Deniz Bayazit, Axel Marmet, Syrielle Montariol, Mary-Anne Hartley, Martin Jaggi and Antoine Bosselut

2024

A gold nanoparticle/peptide vaccine designed to induce SARS-CoV-2-specific CD8 T cells: a double-blind, randomized, phase 1 study in Switzerland

Juliette Besson, Régine Audran, Maxime Karlen, Alix Miauton, Hélène Maby-El Hajjami, Loane Warpelin-Decrausaz, Loredana Sene, Sylvain Schaufelberger, Vincent Faivre, Mohamed Faouzi, et al

2024

MultiModN- Multimodal, Multi-Task, Interpretable Modular Networks

Vinitra Swamy, Malika Satayeva, Jibril Frej, Thierry Bossy, Thijs Vogels, Martin Jaggi, Tanja Kaser and Mary-Anne Hartley

2024

Safety and immunogenicity of a synthetic nanoparticle-based, T cell priming peptide vaccine against dengue in healthy adults in Switzerland: a double-blind,
randomized, vehicle-controlled, phase 1 study

Alix Miauton, Régine Audran, Juliette Besson, Hélène Maby-El Hajjami, Maxime Karlen, Loane Warpelin-Decrausaz,c Loredana Sene, Sylvain Schaufelberger, Vincent Faivre, Mohamed Faouzi, Mary-Anne Hartley, François Spertini, and Blaise Genton

2024

MyThisYourThat for interpretable identification of systematic bias in federated learning for biomedical images

Klavdiia Naumova, Arnout Devos, Sai Praneeth Karimireddy, Martin Jaggi and Mary-Anne Hartley

2024

Automated Interpretation of Lung Sounds by Deep Learning in Children With Asthma: Scoping Review and Strengths, Weaknesses, Opportunities, and Threats Analysis

Isabelle Ruchonnet-Métrailler, Johan N Siebert, Mary-Anne Hartley, Laurence Lacroix

2024

Efficient Classification of Histopathology Images Using Highly Imbalanced Data

Mohammad Iqbal Nouyed, Mary-Anne Hartley, Gianfranco Doretto and Donald A Adjeroh

2024

HashEvict: A Pre-Attention KV Cache Eviction Strategy using Locality-Sensitive Hashing

Minghui Liu, Tahseen Rabbani, Tony O'Halloran, Ananth Sankaralingam, Mary-Anne Hartley, Brian Gravelle, Furong Huang, Cornelia Fermuller, Yiannis Aloimonos

2024

Llama-3 [8B]-MeditronV1. 0—A State-of-the-Art Large Language Model for Medicine in 24 Hours

2024

PLUS-IS-LESS project: Procalcitonin and Lung UltraSonography-based antibiotherapy in patients with Lower rESpiratory tract infection in Swiss Emergency Departments: study protocol for a pragmatic stepped-wedge cluster-randomized trial

Cécile Bessat, Roland Bingisser, Markus Schwendinger, Tim Bulaty, Yvan Fournier, Vincent Della Santa, Magali Pfeil, Dominique Schwab, Jörg D. Leuppi, Nicolas Geigy, Stephan Steuer, Friedemann Roos, Michael Christ, Adriana Sirova, Tanguy Espejo, Henk Riedel, Alexandra Atzl, Fabian Napieralski, Joachim Marti, Giulio Cisco, Rose-Anna Foley, Melinée Schindler, Mary-Anne Hartley, Aurélie Fayet

2024

DeepBreath—automated detection of respiratory pathology from lung auscultation in 572 pediatric outpatients across 5 countries

Julien Heitmann, Alban Glangetas, Jonathan Doenz, Juliane Dervaux, Deeksha M. Shama, Daniel Hinjos Garcia, Mohamed Rida Benissa, Aymeric Cantais, Alexandre Perez, Daniel Müller, Tatjana Chavdarova, Isabelle Ruchonnet-Metrailler, Johan N. Siebert, Laurence Lacroix, Martin Jaggi, Alain Gervaixand Mary Anne Hartley

2023

ePOCT+ and the medAL-suite: development of an electronic clinical decision support algorithm and digital platform for pediatric outpatients in low-and middle-income countries

Rainer Tan, Ludovico Cobuccio, Fenella Beynon, Gillian A Levine, Nina Vaezipour, Lameck Bonaventure Luwanda, Chacha Mangu, Alan Vonlanthen, Olga De Santis, Salim Nahya, Manji Karim, Helga Naburi, Lulu Chirande, Lena Matata Id, Method Bulongeleje, Robert Moshiro, Andolo Miheso, Peter Arimi, Ousmane Ndiaye, Moctar Faye, Aliou Thiongane, Shally Awasthi, Kovid Sharma, Gaurav Kumar, Van Maat Josephine, Kulinkina Alexandra, Victor Rwandarwacu, Théophile Dusengumuremyi, Nkuranga Baptist, John, Emmanuel Rusingiza, Lisine Tuyisenge, Mary-Anne Hartley, Vincent Faivre, Julien Thabard, Kristina Keiteland Valérie D’acremont

2023

Modular Clinical Decision Support Networks (MoDN)—Updatable, interpretable, and portable predictions for evolving clinical environments

Cécile Trottet, Thijs Vogels, Kristina Keitel, Alexandra V. Kulinkina, Rainer Tan, Ludovico Cobuccio, Martin Jaggiand Mary-Anne Hartley

2023

Barriers and facilitators to implementation of point-of-care lung ultrasonography in a tertiary centre in Benin: a qualitative study among general physicians and pneumologists

Veronique Suttels, Sofia Guedes Da Costa, Elena Garcia, Thomas Brahier, Mary-Anne Hartley, Gildas Agodokpessi, Prudence Wachinou, Fabienne Fasseur, Noémie Boillat-Blanco

2023

Deep learning diagnostic and severity-stratification for interstitial lung diseases and chronic obstructive pulmonary disease in digital lung auscultations and ultrasonography: clinical protocol for an observational case–control study

Johan N. Siebert, Mary-Anne Hartley, Delphine S. Courvoisier, Marlène Salamin, Laura Robotham, Jonathan Doenz, Constance Barazzone-Argiroffo, Alain Gervaix & Pierre-Olivier Bridevaux

2023

MEDITRON-70B: Scaling medical pretraining for large language models

Zeming Chen, Alejandro Hernández Cano, Angelika Romanou, Antoine Bonnet, Kyle Matoba, Francesco Salvi, Matteo Pagliardini, Simin Fan, Andreas Köpf, Amirkeivan Mohtashami, Alexandre Sallinen, Alireza Sakhaeirad, Vinitra Swamy, Igor Krawczuk, Deniz Bayazit, Axel Marmet, Syrielle Montariol, Mary-Anne Hartley, Martin Jaggiand Antoine Bosselut

2023

MultiModN- Multimodal, Multi-Task, Interpretable Modular Networks

Vinitra Swamy, Malika Satayeva, Jibril Frej, Thierry Bossy, Thijs Vogels, Martin Jaggi, Tanja Kaserand Mary-Anne Hartley

2023

STUDY PROTOCOL

2022

Predicting Ebola diagnosis and outcome using machine learning: A retrospective cohort study on the 2014-16 West African epidemic

2022

Ultrasound for point-of-care sputum-free tuberculosis detection: Building collaborative standardized image-banks

Véronique Suttels, Prudence Wachinou, Jacques Du Toit, Noémie Boillat-Blancoand Mary Anne Hartley

2022

What If…? Pandemic policy-decision-support to guide a cost-benefit-optimised, country-specific response

Giorgio Mannarini, Francesco Posa, Thierry Bossy, Lucas Massemin, Javier Fernandez-Castanon, Tatjana Chavdarova, Pablo Cañas, Prakhar Gupta, Martin Jaggiand Mary-Anne Hartley

2022

Point-of-care ultrasound for tuberculosis management in Sub-Saharan Africa—A balanced SWOT analysis

Véronique Suttels, Jacques Daniel Du Toit, Arnauld Attannon Fiogbé, Ablo Prudence Wachinou, Brice Guendehou, Frédéric Alovokpinhou, Péricles Toukoui, Aboudou Rassisou Hada, Fadyl Sefou, Prudence Vinasse, Ginette Makpemikpa, Diane Capo-chichi, Elena Garcia, Thomas Brahier, Kristina Keitel, Khadidia Ouattara, Yacouba Cissoko, Seydina Alioune Beye, Pierre André Mans, Gildas Agodokpessi, Noémie Boillat-Blancoand Mary Anne Hartley

2022

Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center

Siméon Schaad, Thomas Brahier, Mary-Anne Hartley, Jean-Baptiste Cordonnier, Luca Bosso, Tanguy Espejo, Olivier Pantet, Olivier Hugli, Pierre-Nicolas Carron, Jean-Yves Meuwly, Noémie Boillat-Blanco

2022

Genomic diversity of torque Teno virus in blood samples from febrile Paediatric outpatients in Tanzania: a descriptive cohort study

Florian Laubscher, Mary Anne Hartley, Laurent Kaiserand Samuel Cordey

2022

Waffle: Weighted averaging for personalized federated learning

Martin Beaussart, Felix Grimberg, Mary-Anne Hartleyand Martin Jaggi

2021

IFedAvg: Interpretable data-interoperability for federated learning

David Roschewitz, Mary-Anne Hartley, Luca Corinziaand Martin Jaggi

2021

Optimal model averaging: Towards personalized collaborative learning

Felix Grimberg, Sai P Karimireddy, Martin Jaggiand Mary-Anne Hartley

2021

Lung Ultrasonography for Risk Stratification in Patients with Coronavirus Disease 2019 (COVID-19)

Thomas Brahier, Jean-Yves Meuwly, Olivier Pantet, Marie-Josée Brochu Vez, Hélène Gerhard Donnet, Mary-Anne Hartley, Olivier Hugliand Noémie Boillat- Blanco

2021

Blood virosphere in febrile Tanzanian children

Samuel Cordey, Florian Laubscher, Mary-Anne Hartley, Thomas Junier, Kristina Keitel, Mylène Docquier, Nicolas Guex, Christian Iseli, Gael Vieille, Philippe Le Mercier, Anne Gleizes, Josephine Samaka, Tarsis Mlaganile, Frank Kagoro, John Masimba, Zamzam Said, Hosiana Temba, Gasser H Elbanna, Caroline Tapparel, Marie-Celine Zanella, Ioannis Xenarios, Jacques Fellay, Valérie D'Acremont, Laurent Kaiser

2021

Lung ultrasonography for risk stratification in patients with coronavirus disease 2019 (COVID-19): a prospective observational cohort study

2021

Deep learning diagnostic and risk-stratification pattern detection for COVID-19 in digital lung auscultations: clinical protocol for a case–control and prospective cohort study

A Glangetas, Hartley MA, Cantais A, Courvoisier DS, Rivollet D, Shama DM, Perez A, Spechbach H, Trombert V, Bourquin S, Jaggi M, Barazzone-Argiroffo C, Gervaix Aand Siebert JN

2021

Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center

2021

Weight erosion: An update aggregation scheme for personalized collaborative machine learning

Felix Grimberg, Mary Anne Hartley, Martin Jaggiand Sai Praneeth Karimireddy

2020

Precision global health: a roadmap for augmented action

Danny J. Sheath, Rafael Ruiz de Castañeda, Nefti-Eboni Bempong, Mario Raviglione, Catherine Machalaba, Michael S. Pepper, Effy Vayena, Nicolas Ray, Didier Wernli, Gérard Escher, Francois Grey, Bernice S. Elger, Dirk Helbing, Kaj-Kolja Kleineberg, David Beran, J. Jaime Miranda, Mark D. Huffman, Fred Hersch, Fred Andayi, Samuel M. Thumbi, Valérie D’Acremont, Mary-Anne Hartley, Jakob Zinsstag, James Larus, María Rodríguez Martínez, Philippe J. Guerin, Laura Merson, Vinh-Kim Ngyuen, Frank Rühli, Antoine Geissbuhler, Marcel Salathé, Isabelle Bolon, Catharina Boehme, Seth Berkley, Alain-Jacques Valleron, Olivia Keiser, Laurent Kaiser, Isabella Eckerle, Jürg Utzingerand Antoine Flahault

2020

Lung ultrasonography for risk stratification in patients with coronavirus disease 2019 (COVI-19): a prospective observational cohort study.

2020

Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: a cohort study

Mary-Anne Hartley, Natalie Hofmann, Kristina Keitel, Frank Kagoro, Clara Antunes Moniz, Tarsis Mlaganile, Josephine Samaka, John Masimba, Zamzam Said, Hosiana Temba, Iveth Gonzalez, Ingrid Felger, Blaise Gentonand Valérie D’Acremont

2020

Machine-learning prognostic models from the 2014–16 Ebola outbreak: data-harmonization challenges, validation strategies, and mHealth applications

Andres Colubri, Mary Anne Hartley, Matthew Siakor, Vanessa Wolfman, August Felix, Tom Sesay, Jeffrey G. Shaffer, Robert F. Garry, Donald S. Grant, Adam C. Levineand Pardis C. Sabeti

2019

Nearly complete genome sequence of a novel phlebovirus-like virus detected in a human plasma sample by high-throughput sequencing

Florian Laubscher, Samuel Cordey, Mary-Anne Hartley, Gael Vieille, Noémie Boillat-Blanco, Josephine Samaka, Tarsis Mlaganile, Valerie D’Acremontand Laurent Kaiser

2019

Novel Rhabdovirus and an almost complete drain fly transcriptome recovered from two independent contaminations of clinical samples

Francisco Brito, Mosè Manni, Florian Laubscher, Manuel Schibler, Mary-Anne Hartley, Kristina Keitel, Tarsis Mlaganile, Valerie d’Acremont, Samuel Cordey, Laurent Kaiser, Evgeny M Zdobnov

2019

Detection of dicistroviruses RNA in blood of febrile Tanzanian children

Samuel Cordey, Florian Laubscher, M.-A. Mary Anne Hartley, Thomas Junier, F.J. Francisco J. Pérez-Rodriguez, Kristina Keitel, Gael Vieille, Josephine Samaka, Tarsis Mlaganile, Frank Kagoro, Noémie Boillat-Blanco, Zainab Mbarack, Mylène Docquier, Francisco Brito, Daniel Eibach, Jürgen May, Peter Sothmann, Cassandra Aldrich, John Lusingu, Caroline Tapparel, Valérie D’Acremontand Laurent Kaiser

2019

THE COMPOSITION AND CLINICAL RELEVANCE OF THE BLOOD VIROME IN FEBRILE PEDIATRIC OUTPATIENTS IN TANZANIA BY UNBIASED NEXT GENERATION SEQUENCING

2019

Machine Learning and mHealth Techniques to Improve Prognostication and Clinical Management of Patients with Ebola Virus Disease

Andres Colubri, Mary-Anne Hartley, Mathew Siakor, Vanessa Wolfman, Tom Sesay, August Felix, Adam C. Levine, Pardis C. Sabeti

2018

Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β

M.-A. Hartley, R.O. Eren, M. Rossi, F. Prevel, P. Castiglioni, N. Isorce, C. Desponds, L.-F. Lye, S.M. Beverley, S.K. Drexlerand N. Fasel

2018

Detection of novel astroviruses MLB1 and MLB2 in the sera of febrile Tanzanian children

Samuel Cordey, M.-A. Mary Anne Hartley, Kristina Keitel, Florian Laubscher, Francisco Brito, Thomas Junier, Frank Kagoro, Josephine Samaka, John Masimba, Zamzam Said, Hosiana Temba, Tarsis Mlaganile, Mylène Docquier, Jacques Fellay, Laurent Kaiserand Valérie D’Acremont

2018

Investigation of the plasma virome from cases of unexplained febrile illness in Tanzania from 2013 to 2014: a comparative analysis between unbiased and VirCapSeq-VERT high-throughput sequencing approaches

Simon H. Williams, Samuel Cordey, Nishit Bhuva, Florian Laubscher, Mary-Anne Hartley, Noémie Boillat-Blanco, Zainab Mbarack, Josephine Samaka, Tarsis Mlaganile, Komal Jain, Valerie D’Acremont, Laurent Kaiserand W. Ian Lipkin

2018

Prognostic models for Ebola virus disease derived from data collected at five treatment units in Sierra Leone and Liberia: performance, external validation, and risk visualization

Andres Colubri, Adam C. Levine, Mathew Siakor, Vanessa Wolfman, Mary-Anne Hartley, Tom Sesay, August Felix, Pardis C. Sabeti

2018

Exacerbated leishmaniasis caused by a viral endosymbiont can be prevented by immunization with its viral capsid

P. Castiglioni, M.-A. Hartley, M. Rossi, F. Prevel, C. Desponds, D.T. Utzschneider, R.-O. Eren, H. Zangger, L. Brunner, N. Collin, D. Zehn, F.M. Kuhlmann,
S.M. Beverley, N. Faseland C. Ronet

2017

Predicting Ebola severity: a clinical prioritization score for Ebola virus disease

Mary Anne Hartley, Alyssa Young, Anh Minh Tran, Harry Henry Okoni-Williams, Mohamed Suma, Brooke Mancuso, Ahmed Al-Dikhariand Mohamed Faouzi

2017

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